Ratner BioMedical Inc.

RBG's Technology Portfolio: Selected Publications

Biomaterials - General

Biomaterials: where we have been and where we are going. Ratner BD, Bryant SJ. Annual Reviews of Biomedical Engineering. 2004;6:41-75.

Cardiovascular Calcification

Osteopontin and calcification

Controlling the orientation of bone osteopontin via its specific binding with collagen I to modulate osteoblast adhesion. Liu L, Qin C, Butler WT, Ratner BD, Jiang S. J Biomed Mater Res A. 2006 Sep 7; [Epub ahead of print]

Arteriosclerosis, calcium phosphate deposition and cardiovascular disease in uremia: current concepts at the bench. El-Abbadi M, Giachelli CM. Curr Opin Nephrol Hypertens. 2005 Nov;14(6):519-24. Review.

Inducers and inhibitors of biomineralization: lessons from pathological calcification. Giachelli CM. Orthod Craniofac Res. 2005 Nov;8(4):229-31. Review.

The role of osteopontin in foreign body giant cell formation. Tsai AT, Rice J, Scatena M, Liaw L, Ratner BD, Giachelli CM. Biomaterials. 2005 Oct;26(29):5835-43. Epub 2005 Apr 21.

Calcification of advanced atherosclerotic lesions in the innominate arteries of ApoE-deficient mice: potential role of chondrocyte-like cells. Rattazzi M, Bennett BJ, Bea F, Kirk EA, Ricks JL, Speer M, Schwartz SM, Giachelli CM, Rosenfeld ME. Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1420-5. Epub 2005 Apr 21.

Controlling osteopontin orientation on surfaces to modulate endothelial cell adhesion. Liu L, Chen S, Giachelli CM, Ratner BD, Jiang S. J Biomed Mater Res A. 2005 Jul 1;74(1):23-31.

Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro. Speer MY, Chien YC, Quan M, Yang HY, Vali H, McKee MD, Giachelli CM. Cardiovasc Res. 2005 May 1;66(2):324-33.

Regulation of vascular calcification: roles of phosphate and osteopontin. Giachelli CM, Speer MY, Li X, Rajachar RM, Yang H. Circ Res. 2005 Apr 15;96(7):717-22. Review.

Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopontin. Ohri R, Tung E, Rajachar R, Giachelli CM. Calcif Tissue Int. 2005 Apr;76(4):307-15. Epub 2005 Apr 11.

Vascular calcification mechanisms. Giachelli CM. J Am Soc Nephrol. 2004 Dec;15(12):2959-64. Review.

Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Yang H, Curinga G, Giachelli CM. Kidney Int. 2004 Dec;66(6):2293-9.

Mechanisms of vascular calcification in uremia. Giachelli CM. Semin Nephrol. 2004 Sep;24(5):401-2.

Enhancing the biological activity of immobilized osteopontin using a type-1 collagen affinity coating. Martin SM, Schwartz JL, Giachelli CM, Ratner BD. J Biomed Mater Res A. 2004 Jul 1;70(1):10-9.

Regulation of cardiovascular calcification. Speer MY, Giachelli CM. Cardiovasc Pathol. 2004 Mar-Apr;13(2):63-70. Review.

Characterization and analysis of osteopontin-immobilized poly(2-hydroxyethyl methacrylate) surfaces. Martin SM, Ganapathy R, Kim TK, Leach-Scampavia D, Giachelli CM, Ratner BD. J Biomed Mater Res A. 2003 Oct 1;67(1):334-43.

Vascular calcification: in vitro evidence for the role of inorganic phosphate. Giachelli CM. J Am Soc Nephrol. 2003 Sep;14(9 Suppl 4):S300-4. Review.

Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Steitz SA, Speer MY, McKee MD, Liaw L, Almeida M, Yang H, Giachelli CM. Am J Pathol. 2002 Dec;161(6):2035-46.

Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. Speer MY, McKee MD, Guldberg RE, Liaw L, Yang HY, Tung E, Karsenty G, Giachelli CM. J Exp Med. 2002 Oct 21;196(8):1047-55.

Tissue Engineering and Regeneration

Development of an esophagus acellular matrix tissue scaffold. Bhrany AD, Beckstead BL, Lang TC, Farwell DG, Giachelli CM, Ratner BD. Tissue Eng. 2006 Feb;12(2):319-30.

Esophageal epithelial cell interaction with synthetic and natural scaffolds for tissue engineering. Beckstead BL, Pan S, Bhrany AD, Bratt-Leal AM, Ratner BD, Giachelli CM. Biomaterials. 2005 Nov;26(31):6217-28.

Cell sheet detachment affects the extracellular matrix: a surface science study comparing thermal liftoff, enzymatic, and mechanical methods. Canavan HE, Cheng X, Graham DJ, Ratner BD, Castner DG. J Biomed Mater Res A. 2005 Oct 1;75(1):1-13.

Tissue engineering of perfused microvessels. Neumann T, Nicholson BS, Sanders JE. Microvasc Res. 2003 Jul;66(1):59-67.

Myocyte cultures on polymer fiber arrays. Neumann T and Sanders JE. Tissue Engineering 2003 vol. 9(5): 995-1003.

Relative influence of polymer fiber diameter and surface charge on fibrous capsule thickness and vessel density for single-fiber implants. Sanders JE, Cassisi DV, Neumann T, Golledge SL, Zachariah SG, Ratner BD, Bale SD. J Biomed Mater Res A. 2003 Jun 15;65(4):462-7.

Tissue response to microfibers of different polymers: polyester, polyethylene, polylactic acid, and polyurethane. Sanders JE, Bale SD, Neumann T. J Biomed Mater Res. 2002 Nov;62(2):222-7.

Control of in vivo microvessel ingrowth by modulation of biomaterial local architecture and chemistry. Sanders JE, Baker AB, Golledge SL. J Biomed Mater Res. 2002 Apr;60(1):36-43.

Chitosan-alginate as scaffolding material for cartilage tissue engineering. Li Z, Zhang M. J Biomed Mater Res A. 2005 Nov 1;75(2):485-93.

Electrospun chitosan-based nanofibers and their cellular compatibility. Bhattarai N, Edmondson D, Veiseh O, Matsen FA, Zhang M. Biomaterials. 2005 Nov;26(31):6176-84.

Chitosan-alginate hybrid scaffolds for bone tissue engineering. Li Z, Ramay HR, Hauch KD, Xiao D, Zhang M. Biomaterials. 2005 Jun;26(18):3919-28.

Cell growth and function on calcium phosphate reinforced chitosan scaffolds. Zhang Y, Zhang M. J Mater Sci Mater Med. 2004 Mar;15(3):255-60.

Calcium phosphate-chitosan composite scaffolds for bone tissue engineering. Zhang Y, Ni M, Zhang M, Ratner B. Tissue Eng. 2003 Apr;9(2):337-45.

Preparation and histological evaluation of biomimetic three-dimensional hydroxyapatite/chitosan-gelatin network composite scaffolds. Zhao F, Yin Y, Lu WW, Leong JC, Zhang W, Zhang J, Zhang M, Yao K. Biomaterials. 2002 Aug;23(15):3227-34.

Three-dimensional macroporous calcium phosphate bioceramics with nested chitosan sponges for load-bearing bone implants. Zhang Y, Zhang M. J Biomed Mater Res. 2002 Jul;61(1):1-8.

Synthesis and characterization of macroporous chitosan/calcium phosphate composite scaffolds for tissue engineering. Zhang Y, Zhang M. J Biomed Mater Res. 2001 Jun 5;55(3):304-12.

Dermal Wound Healing And Percutaneous Catheters

Quantitative Characterization of Sphere-Templated Porous Biomaterials. A. J. Marshall and B. D. Ratner. American Institute of Chemical Engineers AIChE J, 51: 12211232, 2005

Characterization of an in vitro model for evaluating the interface between skin and percutaneous biomaterials. Fukano Y, Knowles NG, Usui ML, Underwood RA, Hauch KD, Marshall AJ, Ratner BD, Giachelli C, Carter WG, Fleckman P, Olerud JE. Wound Repair Regen. 2006 Jul-Aug;14(4):484-91.

A model for studying epithelial attachment and morphology at the interface between skin and percutaneous devices. Knowles NG, Miyashita Y, Usui ML, Marshall AJ, Pirrone A, Hauch KD, Ratner BD, Underwood RA, Fleckman P, Olerud JE. J Biomed Mater Res A. 2005 Sep 1;74(3):482-8.

Morphological evidence for the role of suprabasal keratinocytes in wound reepithelialization. Usui ML, Underwood RA, Mansbridge JN, Muffley LA, Carter WG, Olerud JE. Wound Repair Regen. 2005 Sep-Oct;13(5):468-79.

Validation of a model for the study of multiple wounds in the diabetic mouse (db/db). Sullivan SR, Underwood RA, Gibran NS, Sigle RO, Usui ML, Carter WG, Olerud JE. Plast Reconstr Surg. 2004 Mar;113(3):953-60.

Nerve growth factor accelerates wound healing in diabetic mice. Muangman P, Muffley LA, Anthony JP, Spenny ML, Underwood RA, Olerud JE, Gibran NS. Wound Repair Regen. 2004 Jan-Feb;12(1):44-52.

Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus. Gibran NS, Jang YC, Isik FF, Greenhalgh DG, Muffley LA, Underwood RA, Usui ML, Larsen J, Smith DG, Bunnett N, Ansel JC, Olerud JE. J Surg Res. 2002 Nov;108(1):122-8.

Neutral endopeptidase inhibition in diabetic wound repair. Spenny ML, Muangman P, Sullivan SR, Bunnett NW, Ansel JC, Olerud JE, Gibran NS. Wound Repair Regen. 2002 Sep-Oct;10(5):295-301.

Ultrasound-Mediated Drug Delivery Via Subcutaneous Implants

Ultrasonically controlled release of ciprofloxacin from self-assembled coatings on poly(2-hydroxyethyl methacrylate) hydrogels for Pseudomonas aeruginosa biofilm prevention. Norris P, Noble M, Francolini I, Vinogradov AM, Stewart PS, Ratner BD, Costerton JW, Stoodley P. Antimicrob Agents Chemother. 2005 Oct;49(10):4272-9.

Surface modification of polymers with self-assembled molecular structures: multitechnique surface characterization. Kwok CS, Mourad PD, Crum LA, Ratner BD. Biomacromolecules. 2000 Spring;1(1):139-48.

Self-assembled molecular structures as ultrasonically-responsive barrier membranes for pulsatile drug delivery. Kwok CS, Mourad PD, Crum LA, Ratner BD. J Biomed Mater Res. 2001 Nov;57(2):151-64.

Design of infection-resistant antibiotic-releasing polymers: I. Fabrication and formulation. Kwok CS, Wan C, Hendricks S, Bryers JD, Horbett TA, Ratner BD. J Control Release. 1999 Dec 6;62(3):289-99.